From Fig 6A, it can be seen that the target gene set related to hsa-mir-371a was significantly enriched in several terms closely related to breast cancer, including Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, pathways in cancer, mitotic cell cycle process, and Signaling by Rho GTPases. This evidence concerns the gene SMAD4 and cancer.