NPC2 and cancer: These gene sets were derived from the integration of scRNA-seq from 28 GBM and 401 bulk RNA-seq profiles from The Cancer Genome Atlas and correspond to cell cycle (G1/S, G2/M), hypoxic and non-hypoxic mesenchymal (MES)-like (MES-1 and MES-2, respectively), astrocytic (AC)-like, oligodendrocyte precursor (OPC)-like, and neural progenitor (NPC)-like (NPC1 and NPC2).2 For factors exhibiting a clear temporal pattern, we appended the term “early” to the factor annotation if the factor primarily has high expression before day 42 or “late” if it mainly has high expression after day 42.