CD8A and nonpapillary renal cell carcinoma: In both ccRCC and nccRCC, the T effector signature positively correlated with the presence of cytotoxic lymphocytes (Spearman’s ρ = 0.9; P < 0.001), T cells/CD8+ T cells (ρ = 0.9; P < 0.001), NK cells (ρ = 0.7; P < 0.001), monocytic lineage (ρ = 0.6; P < 0.001), and myeloid dendritic cell abundance (ρ = 0.6; P < 0.001), as well as with a “T cell–inflamed” signature that has been associated with response to immunotherapy (ρ = 0.9; P < 0.001) and the expression of multiple immune checkpoint genes (ρ = 0.05 to 0.8; P < 0.001) (Figure 4A).