SETD2 and nonpapillary renal cell carcinoma: For example, SETD2 mutations were associated with lower stromal scores in ccRCC with sarcomatoid/rhabdoid features (mean Z score difference, –0.87; P < 0.05) but higher stromal scores in ccRCC without sarcomatoid/rhabdoid features (mean Z score difference, –0.87; P < 0.05).