Mutations in the nuclear receptor subfamily 2 group E member 3 (NR2E3) gene cause enhanced S-cone syndrome (ESCS) (OMIM 268100), a congenital retinal disease characterized by night blindness, hypersensitivity to short-wavelength light, and eventual loss of visual acuity (9, 10). This evidence concerns the gene NR2E3 and Abnormal retinal morphology.