NLRC4 and rectum adenocarcinoma: To further validate this, we found that NLRC4 expression (but not NLRP6 used as control) was also correlated with a broader unbiased type I IFN gene signature (encompassing 59 genes, see Methods) in colon COAD and rectum adenocarcinoma (READ) patient tumors (r = 0.46, P < 2.2 × 10–16; r = 0.53, P = 5.2 × 10–14, respectively), as well as in LUSC and LUAD patient lung tumors (Figure 4B).