Consistent with this, it was previously shown that absence of NLRC4 expression in Nlrc4–/– mice promotes colon tumorigenesis in the azoxymethane (AOM)/dextran sodium sulfate (DSS)–induced inflammatory CRC model wherein tumors appeared aggressive, with invasion of tumor cells below the muscular mucosae (10). This evidence concerns the gene NLRC4 and colorectal carcinoma.