To confirm and extend this finding in human disease, we observed that NLRC4 expression (but not NLRP10 used as control) strongly correlated with expression of the type I IFN genes induced in the NLRC4-expressing cell lines (as described in Figure 3C) in various patient cancer samples (colon, lung, and melanoma) (Figure 4A). The gene discussed is NLRC4; the disease is melanoma.