Importantly, consistent with our finding showing a role for NLRC4 in protecting against metastatic progression in CRC, expression of NLRC4 (but not NLRP10) and type I IFN genes was associated with a significantly lower risk of metastasis in patients with skin cutaneous melanoma (SKCM) (Figure 4C). Here, NLRP10 is linked to colorectal carcinoma.