BRD4 and neoplasm: To confirm the relationship between Yap1 and ColVI in UPS with a pharmacologic approach, we treated tumor-bearing KP mice and KP cells in vitro with the histone deacetylase inhibitor (HDACi) vorinostat, also known as suberoylanilide hydroxamic acid (SAHA), and the BRD4 inhibitor JQ1, or vehicle control.