To confirm the relationship between Yap1 and ColVI in UPS with a pharmacologic approach, we treated tumor-bearing KP mice and KP cells in vitro with the histone deacetylase inhibitor (HDACi) vorinostat, also known as suberoylanilide hydroxamic acid (SAHA), and the BRD4 inhibitor JQ1, or vehicle control. This evidence concerns the gene YAP1 and neoplasm.