Moreover, the functions of some differentially expressed proteins identified in our study have been previously investigated (46, 63–68); several EMT-related proteins, such as WNT5A, MMP1, MMP2, MMP14, LAMC2, FN1, and COL5A2, have been found to enhance cancer cell migration and invasion, suggesting their potential involvement in metastasis. Here, MMP1 is linked to cancer.