A series of proteins, including GAR1, PRKDC, SRSF9, SRSF6, SFPQ, RB1, TP63, and translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), were associated with a high prognosis risk score; among those proteins, PRKDC, RB1, and TP63 have been previously reported (39) in ESCC (Figure 3G). The gene discussed is TIMMDC1; the disease is esophageal squamous cell carcinoma.