In our study of LBC cases associated with germline CDH1 variants, 11 of 12 (91.7%) manifested a somatic alteration (7 of 12 [58.3%], sequence variations; 6 of 12 [50.0%], intragenic LOH; 3 of 12 [25.0%], promoter methylation)(Table 2 and Table 3). The gene discussed is CDH1; the disease is CDH1-related diffuse gastric and lobular breast cancer syndrome.