With a median 5.24 years of follow-up (IQR, 4.93-5.67 years), no associations were observed among germline CDH1 variant carriers, BRCA1 and BRCA2 genes, wild-type groups, and the clinical-pathological features of LBC (eTables 5 and 6 in Supplement 1). This evidence concerns the gene CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome.