Conversely, a CDH1 c.833-476_1138-464del carrier, who was previously tested following a diagnosis of bilateral LBC and then enrolled in this study, had already undergone PTG at enrollment, and gastric histopathological analysis revealed 3 foci of invasive DGC (pT1aN0). Here, CDH1 is linked to CDH1-related diffuse gastric and lobular breast cancer syndrome.