In an ongoing independent study by our team testing only sporadic LBC (LobularCard Breast trial), the frequency of P/LP variants was 0.9% in BRCA1 and 2.2% in BRCA2 genes, and no P/LP CDH1 variants were identified (eTable 9 in Supplement 1). Here, BRCA1 is linked to CDH1-related diffuse gastric and lobular breast cancer syndrome.