TNF and autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive: Since HeLa cells expressing OTULINL272P show much higher levels of TNF-dependent auto-linear ubiquitination of LUBAC subunits than cells expressing OTULINY244C or OTULINR306Q (Fig. 4 D), the severity of ORAS symptoms appears to correlate with residual OTULIN function rather than with the mode of inheritance.