Several OTULIN variants are associated with an autoinflammatory disease called ORAS (Table S3) (Damgaard et al., 2016, 2019; Nabavi et al., 2019; Zhou et al., 2016; Zinngrebe et al., 2022). Here, OTULIN is linked to autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.