Furthermore, the MCU inhibitor (Ru360) attenuates neuronal death in rat hippocampal neurons after a pilocarpine-induced status epilepticus [14], and mice with global MCU deletion showed a disturbance in the generation of gamma oscillation and sharp-wave ripples in hippocampal slice preparations, indicating a crucial role of MCU in generating fast cortical network rhythms [15]. The gene discussed is MCU; the disease is status epilepticus.