Additionally, even if the remaining combination of SNPs and nutrient intakes did not show any significant interaction for CRC risk, the following variants were associated with a decreased risk of CRC among individuals with moderate-high betaine and/or total choline intake, in both the unadjusted and adjusted models (Tables S5 and S6): DNMT3B (rs2424913, rs406193), DNMT1 (rs2228612), MTHFR (rs1801131, rs1801133), MTHFD1 (rs8003379, rs17824591), and Met synthase reductase (rs1801394, rs10380). Here, MTHFR is linked to colorectal carcinoma.