F2RL3, the gene encoding thrombin receptor PAR4, is a regulatory target of HIF-1α in mouse CF, with increased F2RL3 transcription observed in mouse CF exposed to SIB and in ventricular myocardium of mice with permanent LAD occlusion (Kleeschulte et al. 2018). This evidence concerns the gene F2RL3 and cystic fibrosis.