THBD and obesity due to melanocortin 4 receptor deficiency: Accordingly, mice with mutated TF are protected from HFD-induced obesity and insulin resistance (Badeanlou et al. 2011), while mice with a pro-coagulant mutation of the thrombomodulin gene that increases thrombin activity develop accelerated obesity under HFD, associated with localized deposition of pro-inflammatory fibrin in WAT (Kopec et al. 2017).