EAT is strongly associated with atrial fibrillation (AF) burden and outcome after ablation, and after adjustment for left atrial volume and body mass index, periatrial EAT depots of patients with AF exhibited significantly higher levels of CD54 (Girerd et al. 2013), also known as intercellular adhesion molecule (ICAM)-1. The gene discussed is ICAM1; the disease is atrial fibrillation.