PDGFD exhibits the ability to elevate interstitial fluid pressure, facilitate macrophage recruitment, and promote blood vessel maturation during angiogenesis [54], and overexpression of PDGFD resulted in an increase in perivascular cell coverage and the normalization of tumor blood vessels, thereby facilitating the penetration of doxorubicin into the tissue and enhancing its efficacy as a treatment [47]. The gene discussed is PDGFD; the disease is neoplasm.