AQP2 and Polyuria: Therefore, in the present work, we studied the effect of chronic stimulation of β3‐AR in the mouse model of X‐NDI, showing that continuous administration of BRL37344 dramatically corrected the polyuria, the hyposthenuria and the compensatory polydipsia of these animals throughout the 24 h, likely by promoting tubular reabsorption of NaCl, through the activation of NKCC2 and NCC, and water, through AQP2.