Because the Y-complex can selectively affect survival of cancer cells in response to the presence of nutrients (such as high serum and growth factors) (Sakuma et al., 2020), and changes in nutrient availability can lead to NPC reorganization (clustering) in fission yeast (Varberg et al., 2022), we studied how UBAP2L-dependent regulation of Nups can be affected by nutrient deprivation in human cells. The gene discussed is NPC1; the disease is cancer.