Interestingly, deletion of Y-complex Nups can selectively affect survival and proliferation of colon cancer cells in response to presence of nutrients (Sakuma et al., 2020), and UBAP2L is sufficient to restore the NPC density after nutrient deprivation (Fig. 9, L–Q), suggesting that UBAP2L-Nup pathway plays an important role under nutrient stress conditions, which have been previously implicated in the regulation of NPC numbers in fission yeast (Varberg et al., 2022). Here, UBAP2L is linked to malignant colon neoplasm.