UBAP2L (also known as NICE-4) has been associated with various cancer types (Chai et al., 2016; He et al., 2018; Li and Huang, 2014; Ye et al., 2017; Zhao et al., 2015; Guerber et al., 2022), but the cellular mechanisms underlying its oncogenic potential remain unknown. The gene discussed is UBAP2L; the disease is cancer.