For example, in non‐small cell lung cancer (NSCLC), the pyroptosis inducer polyphyllin VI (PPVI), a major saponin isolated from Trillium tschonoskii Maxim (TTM), mediated the occurrence of caspase‐1‐initiated pyroptosis through the ROS/NF‐κB/NLRP3/GSDMD signalling axis and inhibited the proliferation of NSCLC.46 This evidence concerns the gene NLRP3 and non-small cell lung carcinoma.