In constructed mouse models, RIPK1/RIPK3 has the ability to enhance the expression of sin3A‐associated protein 130 (SAP130), CXCL1 and CXCL5, leading to the phenomenon that macrophages polarize towards M2 direction while promoting immunosuppression and tumour metastasis mediated by M2‐type cells.144, 145. This evidence concerns the gene RIPK1 and neoplasm.