It is worth mentioning that ZVI‐NP can convert immunologically heterogeneous M2‐type cells into M1 anti‐tumour‐type cells at the same time can reduce the level of Treg in the TME, in addition, blocking the expression of PD‐1 and CTLA4 on the surface of T cells avoids binding to the tumour cell surface receptor blocking the immune response.192. The gene discussed is CTLA4; the disease is neoplasm.