Furthermore, autophagosomes (TRAPs), an LC3‐II+ double‐membrane extracellular vesicle (ev) secreted by tumour cells, can promote macrophage differentiation towards the M2 phenotype, inhibit the infiltration of CD4+ and CD8+ T cells in the TME and get involved in the construction and maintenance of the immunosuppressive microenvironment.69 This evidence concerns the gene CD4 and neoplasm.