The ability of IL‐6 to initiate ferroptosis is equally striking, which can disrupt intracellular iron homeostasis via JAK/STAT3 while using protein kinase (ERK) as a signalling amplifier inhibition of the antioxidant function of the xc‐system catalyses ferroptosis in tumour cells.118, 119. The gene discussed is STAT3; the disease is neoplasm.