Polymyxin VI (PPVI) uses the ROS/NF‐κB/NLRP3/GSDMD signalling axis to awaken caspase‐1 to complete the cleavage mission of GSDMD to promote pyroptosis in NSCLC cancer cells, demonstrating the potential of PPVI for inhibiting NSCLC progression.46 This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.