First clinical evidence of MET exon 14 skipping tumours responding to a MET TKI was obtained in studies using crizotinib, an ATP-binding competitor of anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), RON, and MET (Paik et al., 2015; Giroux-Leprieur et al., 2016). Here, MET is linked to neoplasm.