MET and non-small cell lung carcinoma: After initial preclinical studies demonstrating MET TKI efficacy in cell lines displaying MET exon 14 skipping mutations (Togashi et al., 2015; Frampton et al., 2015; Engstrom et al., 2017; Cecchi et al., 2016; Bladt et al., 2013), several clinical trials were performed to evaluate the efficacy of MET TKIs in NSCLC patients displaying MET exon 14 skipping.