In support of this, the rs5743708 SNP in TLR2, leading to the amino acid change R753Q that disrupts TLR2 signaling by impairing its tyrosine phosphorylation, dimerization with TLR6, and recruitment of Mal and MyD88 (28), was previously associated with predisposition to invasive fungal disease in patients with acute myeloid leukemia (29). The gene discussed is TLR2; the disease is acute myeloid leukemia.