Supporting a role for phagosome biogenesis and LAP in VAPA, the expression of genes involved in LAP, namely MAP1LC3B (microtubule-associated protein 1 light chain 3 beta) and SQSTM1 (sequestosome-1), was decreased in IAPA and CAPA compared to patients with viral infection alone (16). This evidence concerns the gene SQSTM1 and episodic ataxia type 2.