INS and type 1 diabetes mellitus: It is important to note that numerous Vκ genes were found to be polymorphic in NOD mice relative to the C57BL/6 strain [117], and that several of these polymorphisms (present in CDRs) were confirmed to enhance murine insulin (self-antigen) recognition in the NOD strain compared to C57BL/6 mice expressing the same VH125 transgene, further obscuring the role of BCR somatic hypermutation in T1D development [115].