AhR-dependent repression of FOXM1 was observed in crypts adjacent to colon tumors and tumors, stem and progenitor cells and chromatin immunoprecipitation showed that TCDD induced formation of the AhR:ARNT complex in regions of the FOXM1 promoter containing a cis-acting AhRE binding site (Figure 2B). Here, AHR is linked to colonic neoplasm.