Among them, FNTA, HSPA5, NEU1, CCND1, CASP1, CASP3 had a negative causal association with ovarian cancer development, and HMGCR, PLA2G4A, ITGAL, PTGS1, FNTB had a positive causal association with ovarian cancer development. The gene discussed is HMGCR; the disease is ovarian cancer.