Nevertheless, although they are the least studied ephrins in CRC, few studies have shown a possible loss of signaling of these EphAs during tumor progression, although high expression of EPHA8 has recently been demonstrated in patients with lymph node metastasis, significantly associated with worse prognosis (52) (Table 1). The gene discussed is EPHA8; the disease is metastatic malignant neoplasm in the lymph nodes.