The present study aimed to investigate the potential of TRAMs in the definition of GBM response to dendritic cell IT plus SOC, exploring possible association with known biomarkers such as O6-methylguanine-DNA-methyltransferase (MGMT) hypermethylation and to assess their diagnostic value in the distinction of PsP and TTP during IT. This evidence concerns the gene MGMT and glioblastoma.