Infections, allergens (177), and exposure to environmental risk factors (e.g., UV, radiation, stress, mechanical trauma, and hypoxia) can activate a wide array of receptors, including PRRs (pattern recognition receptors) (e.g., TLRs, NLRs, RLRs), FC receptors, P2Y receptors (P2YR) (178, 179), MHC (major histocompatibility complex) class II (180, 181) and complement receptors (C3a and C5a) (182–184) on mast cells and eosinophils via binding to their cognate ligands. This evidence concerns the gene HLA-C and infection.