Canonical pathway analyses on cytokines with z score value of plus minus 1 or more revealed significant inhibition in several pathways, notably the pathogen-induced cytokine storm signaling pathway (-log (B-H p-value)= 27; z-score = -1.15) (Supplementary Table S4), neuroinflammation (-log (B-H p-value)= 4.1; z-score = -2.24), HMGB1 (High Mobility Group Box 1) signaling (-log (B-H p-value)= 8.36; z-score = -1.34), and Systemic Lupus Erythematosus in T cell signaling pathway (-log (B-H p-value)=2.78; z-score: -1.34) (Figure 5A; Supplementary Table S3). Here, HMGB1 is linked to systemic lupus erythematosus.