While specific cytokine changes, including the reduction in SFAS/FASLG, VEGF, CTACK/CCL27, IL9, IL6, MCP4, IL10, IL4, and increases in ENA78, GROA, IL2, TRACE, CCL21, FGF2, IL33, and TPO, did not achieve statistical significance individually, their collective alterations, as indicated by Z scores, may reveal a significant impact on the cytokine landscape in ME/CFS. Here, CCL21 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.