Given that TIGIT and KLRG1 co-expression were identified in peripheral blood of T1D subjects, the T1D EOMES signature (12) best discriminated transcriptional profiles of TIGIT+KLRG1+ and TIGIT-KLRG1- populations (K-S test, P = 9.8e-10). The gene discussed is TIGIT; the disease is type 1 diabetes mellitus.