TEX levels do not differ at baseline, but the TEX that expand following therapy in T1D co-express inhibitory receptors including TIGIT, PD-1, and KLRG1, and share an EOMES gene signature that overlaps with exhaustion and differs from senescence (14), suggesting an exhausted-like phenotype (12, 13). The gene discussed is KLRG1; the disease is type 1 diabetes mellitus.