To determine whether TIGIT+KLRG1+ memory CD8+ T cells are similar across disease settings, we compared EOMES module expression in sorted TIGIT+KLRG1+ memory CD8+ T cells and TIGIT-KLRG1- memory CD8+ T cells from HC, individuals with T1D, and individuals with RCC; RCC was included because cancer is a setting where exhaustion is expected (1). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.