In addition, while the RA HLA-TEX association is recapitulated in baseline samples from abatacept- (CTLA4Ig) treated RA subjects, it was not in the adalimumab (anti-TNF) RA treatment cohort; although, this may be due to higher baseline TEX proportions; TEX were significantly higher (P = 0.0036) at baseline in adalimumab- as compared to abatacept-treated RA subjects. Here, TNF is linked to rheumatoid arthritis.