AKT1 and cancer: The functional enrichment analysis disclosed that the cancer-related regulation pathways were mainly activated in the high-PMRS group, including E2F_targets (Kent and Leone, 2019), PI3K_AKT_MTOR (He et al., 2021), and epithelial–mesenchymal transition (EMT) (Dongre and Weinberg, 2019), so these may mechanistically explain the tumor progression and unfavorable prognosis observed in patients belonging to the high-PMRS group.