MYC and cancer: Furthermore, functional enrichment analysis revealed that activated pathways were mainly cancer-related in the high-PMRS group, such as E2F_targets, G2M_checkpoint, MYC_targets_V1, MYC_targets_V2, EPITHELIAL_MESENCHYMAL_TRANSITION, MITOTIC spindle, and PI3K_AKT_MTOR_signaling (Figure 8A).