Generally speaking, SIGLECs are of great importance in various situations, including their systematical changes with COAD, affecting COAD prognosis, co-evolve with other genes in COAD, its strong correlation with immunotherapy, etc. Through the PCA approach, we identified SIGLEC-1,14,15 plays the most important roles in COAD (Figures 1–4), while through the DEG-PPI approach, we identify SIGLEC-1,15 and CD22 are the hub genes (Figure 8). This evidence concerns the gene SIGLEC1 and colon adenocarcinoma.