In cDC cells, HLA DR on myeloid DC (p = 0.005, OR = 1.134, 95%CI = 1.037–1.240) and HLA DR on plasmacytoid DC (p = 0.004, OR = 1.139, 95%CI = 1.041–1.246) showed a positive causal relationship, while CD62L on CD62L + plasmacytoid DC (p = 0.034, OR = 0.805, 95%CI = 0.658–0.984); CD62L-monocyte %monocyte (p = 0.042, OR = 0.854, 95%CI = 0.734–0.994); and CD86+ plasmacytoid DC %DC (p = 0.006, OR = 0.800, 95%CI = 0.682–0.939) showed a negative causal relationship with the development of osteomyelitis. Here, SELL is linked to osteomyelitis.