This has led to the popular proposal of investigating Alzheimer’s disease as a Type 3 diabetes mellitus.12 Interestingly, SORLA has been shown to be a regulator of metabolism, as it recycles internalized insulin receptors to the plasma membrane, in turn increasing insulin sensitivity.13 Therefore, neuronal SORLA is a potential link between metabolic dysfunction and neurodegeneration in Alzheimer’s disease. This evidence concerns the gene INS and early-onset autosomal dominant Alzheimer disease.