This idea has spun from the extensive cortical hypometabolism observed with fluorodeoxyglucose PET (FDG-PET) in patients with Alzheimer’s disease.10 Though still a young field of research, a significant overlap has been observed between risk factors and assumed pathophysiological mechanisms of Type 2 diabetes mellitus and Alzheimer’s disease.11 The Alzheimer’s disease brain seems to be insulin resistant, even in the absence of Type 2 diabetes mellitus. The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.