The pathogenesis of diabetic retinopathy is related to inflammation and fibrosis (23), and it has been reported that the production of pro-inflammatory cytokines such as IL-1, TNF-α, and VEGF increases in the vitreous body of patients with diabetic retinopathy and in animal models of the retina (22, 24). The gene discussed is TNF; the disease is diabetic retinopathy.