Interestingly, the PLAA null-mice models revealed an embryonic lethality, in contrast the mice with homozygous missense mutation and compound heterozygous in PLAA are born and display early-onset brain developmental and neurodegenerative disorders, highlighting a smaller brain with tremor and motor disorders, including altered gait, hypomotility, and neuromuscular weakness. This evidence concerns the gene PLAA and Tremor.