TNFSF13B and Autoimmunity: Indeed, increased anxiety-like behaviors (open field, elevated plus maze, novelty suppressed feeding), evidence of neuroinflammation (reactive astrocytes, activated microglia), impaired hippocampal neurogenesis, and disrupted long-term potentiation were found in BAFF overexpressing transgenic mice, a common preclinical model of autoimmunity (Crupi et al., 2010).