A two-fold increase for the Igf2 gene (strongly linked to spermatogenesis, sex determination, testis development, infertility and prostate cancer; Damaschke et al., 2017; Neirijnck et al., 2019; Cannarella et al., 2020; Matsuzaki et al., 2020) has been also observed. Here, IGF2 is linked to Infertility.