To date, only two reports have described a role for the Tcte1 gene: as a mice model of infertility, where the Tcte1-null sperm cells exhibited asthenozoospermia, or in a group of patients without a clear explanation of the linkage between the observed variant and sperm phenotype (Castaneda et al., 2017; Zhou et al., 2022). Here, DRC5 is linked to Infertility.