DRC5 and Reduced sperm motility: That leads to the conclusion that homozygous Tcte1 mutation results not only in an inflexible midpiece leading to asymmetric circular motility, as presented in this study and by others (Fung et al., 2018), and then to asthenozoospermia, but also to aberrant functioning of mitochondrial OXPHOS machinery leading to the disruption of ATP production.