As the above studies showed, several effective metabolites of Sishen Pill, such as psoralen, isoeugenol, and evodiamine, can downregulate the expression of VEGF and MMP proteins (Li et al., 2019a; Feng et al., 2021; Bilgin et al., 2023), thus promoting the apoptosis and having a therapeutic effect in colon cancer (Figure 3A). The gene discussed is VEGFA; the disease is malignant colon neoplasm.