These data indicate that ferroptosis plays a crucial role in cerebral ischemia-reperfusion injury, and this is the first time that a significant neuroprotective effect of BCP in reducing ischemic stroke damage has been discovered, which is closely related to the regulation of ferroptosis, possibly involving the activation of the NRF2/HO-1 axis. Here, NFE2L2 is linked to Cerebral ischemia.