Huang QX et al. (Huang et al., 2023) confirmed through in vitro and in vivo models that GCK pretreatment could alleviate Drp1 mitochondrial translocation, mitochondrial autophagy, mitochondrial apoptosis, and neuronal bioenergetic imbalance, thus inhibiting stroke ischemia-reperfusion injury. This evidence concerns the gene GCK and stroke disorder.