PHB2 and Cerebral ischemia: Subsequently, they found that ART increased the conversion of LC3I to LC3II after chloroquine-induced inhibition of the lysosomal pathway, silenced PHB2, thereby inhibiting the conversion of LC3I to LC3II and impairing mitochondrial autophagy.This study demonstrates that ART alleviates OGD/R-induced oxidative stress damage through PHB2-mediated mitochondrial autophagy in human neuroblastoma SH-SY5Y cell line, providing new insights for the treatment of oxidative damage induced by cerebral ischemia-reperfusion in clinical practice.