Fortunately, increasing evidence shows that many medicinal plants and their active metabolites can not only act through multiple targets but also consider multiple targets (such as NIX, BNIP3, FUNDC1, GPX4, FSP1, and so on) in cerebral ischemia-reperfusion injury, such as mitochondrial autophagy and ferroptosis. This evidence concerns the gene BNIP3L and brain ischemia.