With constant damage during food digestion, the intestinal epithelium is self‐renewed every 4–7 days, thus becoming the most highly regenerative tissue in the human body.[20a] Under pathological conditions, such as inflammation and infection, intestinal cell apoptosis dramatically increases, together with tissue damage.[22] After the induction of T‐bet expression, we observed dramatically enhanced caspase 3/7+ apoptotic cells in the mouse intestine and structural damage in tissue organoids, confirming that T‐bet promotes apoptosis in gut epithelial cells. Here, CASP3 is linked to infection.