We next determined several Co-IRs and activation markers including TIGIT, PD1, TIM3, CD160, HLA-DR, CD38 and CD127 expression on CD3+/CD4+/CD8+ T cells and analyzed the performance of their correlation with a series of clinical manifestations, disease activity and laboratory features including presence of nephritis (proteinuria < 0.5gm vs. > 0.5gm), decreased complement component 3 (C3) and/or complement component 4 (C4), disease activity (SLEDAI > 6) and ds-DNA antibody production. The gene discussed is C3; the disease is nephritis.