SLE patients had decreased levels of SLAMF7 and SLAMF4 (CD244) on memory CD8 + T cells, suggesting deficient antiviral effector function with inadequate effector CD8 + T cell degranulation capacity and a proportion of IFN-producing cells in response to antigen stimulation [42, 43]. The gene discussed is SLAMF7; the disease is systemic lupus erythematosus.