In SLE with ESRD patients, CD38, PLEK (platelet and leukocyte C kinase substrate and the KSTR sequence of amino acids), interferon-γ, CX3CR1, fibroblast growth factor binding protein type 2 (FGFBP2), and solute carrier organic anion transporter family member 4C1 (SLCO4C1) were significantly downregulated on CD4 and CD8 T cells simultaneously. This evidence concerns the gene CX3CR1 and systemic lupus erythematosus.