Table 2 presented that SLE patients possess a surge in CD45RA-CD197-8 + GZMB + CD8 T cells (9.320 ± 1.169%, (N = 25) vs. 26.32 ± 2.474%, (N = 38), p =  < 0.0001), CD45RA-CD8 + CD103-CD161- GZMK + T cells (4.207 ± 0.6274%, (N = 25) vs. 6.989 ± 1.461%, (N = 38), p = 0.1432), and CD45RA-CD8 + CD103-CD161- GZMK + GZMB + T cells (1.874 ± 0.2710%, (N = 25) vs. 6.989 ± 1.461%, (N = 38), p = 0.0365) than healthy controls. This evidence concerns the gene GZMB and systemic lupus erythematosus.