PRF1 and lobular neoplasia: As depicted in the Supplemental Figures, the gene list best defining the pathways suggests that the NK cytotoxicity signature (KIR2DL3, CD94, FcγR, perforin, granzyme and Fas/Fas ligand induced apoptosis), graft versus host disease (MHC class II antigen processing and type I interferon and host target tissue injury), and chemokine-cytokine interaction (CCL4 and CX3CR1) significant influence the pathogenesis of advanced LN.