Also, TIM3 (12.56 ± 0.9711%, (N = 91) vs. 9.826 ± 1.19% (N = 27), p = 0.1534; MFI: 444.3 ± 7.502 vs. 384.9 ± 12.23, p = 0.0002), TIGIT (35.06 ± 1.65%, (N = 90) vs. 25.81 ± 1.774% (N = 27), p = 0.0042) and HLA-DR (46.74 ± 2.319% (N = 51) vs. 18.6 ± 1.909% (N = 17), p < 0.0001; MFI: 740.2 ± 31.93 vs. 547.2 ± 24.81, p = 0.0013) expression on CD8+ T cells were higher in patients with SLE. The gene discussed is HAVCR2; the disease is systemic lupus erythematosus.