Subsequent studies revealed intracellular signal transduction through CARD9-aided NFκB activation, resulting in NLGP-induced alterations in the cytokine-secretion profile of DCs, which later manifests on to the production of multidirectional systemic effects of NLGP leading to regression of tumor growth [12] and metastasis [22]. This evidence concerns the gene NFKB1 and neoplasm.