Chen et al. [71]uncovered that contrast agents cause kidney injury, up-regulate the protein expression of Caspase-1, NLRP3, ASC and GSDMD, and promote the release of IL-1β, IL-18 and lactate dehydrogenase (LDH), indicating that the classical NLRP3-Caspase-1-GSDMD pathway is implicated in CI-AKI pathogenesis. The gene discussed is GSDMD; the disease is acute kidney injury.