Through scRNA-seq analysis in human tumor samples, Lymphocyte-activation gene 3 (LAG3), T-cell Immunoglobulin and Mucin-domain containing-3 (TIM3), and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were upregulated and co-expressed in CD8+ T-cells. This evidence concerns the gene LAG3 and neoplasm.