For the patients with abnormal AST and ALT, on the hand, CD4 + T cells(average ratio:36.67%) and CD8 + T cells(average ratio:24.65%) were decreased, which might be explained by that elevated exhaustion levels T cells was derived from immune dysregulation caused by severe infection [24]; On the other hand, NK cells(average ratio:7.87%) and CD19 + cells(average ratio:27.11%) were increased slightly caused by ADV infection(Supplementary Fig. 4). This evidence concerns the gene CD8A and infection.