However, there are few studies which have investigated the expression of miR-141-3p and miR-421 in COVID-19 patients, in the present study, we aimed to investigate the serum levels of sACE2 and Ang II, as well as the expression levels of miR-141-3p and miR-421 in SARS-CoV-2-positive and negative subjects. Here, AGT is linked to COVID-19.