(3) GIST and NET, as common submucosal tumors in the stomach, can be distinguished from GHIP through immune phenotypes (including immunohistochemical staining for CD34、CD117、DOG1 and Chromogranin A).The polyp-type GHIPs can be resected endoscopically by EMR, but for SMT-type especially larger than 20 mm in diameter, ESD is practical for en bloc resection currently [1, 3, 6, 13, 14, 16, 18, 19, 21, 24–26, 28, 29, 37], which is consistent with our present 10 cases. This evidence concerns the gene ANO1 and gastrointestinal stromal tumor.