reported that in a cuprizone‐induced demyelination model, microglia lacking TREM2 could effectively phagocytose myelin debris, yet they exhibited impaired clearance of cholesterol, leading to the accumulation of intracellular cholesterol; this inability to clear cholesterol might be mediated by the cholesterol transport system liver X receptor (LXR).28 The gene discussed is TREM2; the disease is Peripheral demyelination.