Consistent with the published data on the relationship between SDCBP and EGFR, in our previous study, SDCBP was abundantly expressed in ESCC and accelerated the formation of ESCC tumors by interacting with EGFR and initiating the EGFR-PI3K-Akt signaling pathway26. This evidence concerns the gene EGFR and esophageal squamous cell carcinoma.