To elucidate whether CK2α-mediated phosphorylation of GRP94 at S306 was responsible for CK2α-induced invasion and migration of breast cancer cells, we assessed expression levels of key factors related to Wnt signaling and EMT in CK2α-depleted or GRP94 mutants expressing MDA-MB231 cells. This evidence concerns the gene HSP90B1 and breast cancer.