SIRT2 and cancer: Among the cytosolic deacetylases responsible for the deacetylation of nonhistone proteins (i.e., HDAC6, SIRT1, and SIRT2), the expression of SIRT1/2 was considerably higher in cancer cells (i.e., A549 and HCC1806 cells) than in normal tissue cells (i.e., BEAS-2B and HMLE cells; Fig. 6D; Appendix Fig. S3D).