By contrast, the overexpressed miR-6126 mimics suppressed their target, GRP78 mRNA (Kha, 2018), in both P2- and P2S-treated A549 cancer cells (Fig. 3H, right panel), suggesting that miR-6126-mediated mRNA suppression does not depend on Ago2/CAV1 interaction. This evidence concerns the gene HSPA5 and cancer.