While the substitution of Ago2 lysine 212 with alanine decreased the interaction with CAV1 proteins (Fig. 6B, HA-Ago2K212A; Appendix Fig. S3B), CAV1 proteins remained coprecipitated with HA-Ago2K212R (Fig. 6B; Appendix Fig. S3B) in HEK293, A549, and HCC1806 cancer cells. The gene discussed is CAV1; the disease is cancer.