AGO2 and cancer: Since EMT in cancer cells contributes to drug resistance (Singh and Settleman, 2010; Voulgari and Pintzas, 2009), stemness (Mani et al, 2008; Singh and Settleman, 2010), and invasiveness (Brabletz et al, 2005) of cancer cells, we examined the effects of Ago2/CAV1 interaction on these cancer cell properties.