AGO2 and cancer: It corresponds with our observation that blocking Ago2/CAV1 interaction disrupts Ago2 association with the plasma membranes, which contain abundant CAV1 (Figs. 2H,I, 6G), but does not significantly interfere with Ago2 association with endosomes and ER, which only contain slight CAV1, in the cancer cells (Figs. 2Div, Dvi, 6G and EV2E).