In normal epithelial cells, Ago2 was not co-located with CAV1 on the plasma membranes (Figs. 2F and EV2F, arrows), whereas in cancer cells, Ago2 proteins were co-located with CAV1 on the plasma membranes (Figs. 2F and EV2F, arrowheads). This evidence concerns the gene AGO2 and cancer.