Quantitative PCR analysis of EV miRNA-3613-3p, miRNA-877-5p, and miRNA-6126 in the plasma of patients with breast cancer at different stages showed that only miRNA-3613-3p was increased in the plasma of patients at stage II and stage IV; such patients had invasive and metastatic tumors with increased Ago2/CAV1 interaction (Fig. 9H). Here, AGO2 is linked to metastatic neoplasm.