GLS and cancer: In cancers like osteosarcoma, both isoforms are involved, with heightened expression correlating with increased glycolysis and glutaminolysis, driving tumor growth and metastasis.In the hFAHD1.1 wild-type overexpressing cells, a downregulation of KGA protein (as observed through Western Blot analysis) was noted, whereas in the T192S samples, an upregulation was observed.