Furthermore, 13 patients with compound heterozygous Hb Malay, harboring various β-thalassemia point mutations [e.g., NT-28 (A>G), codon 17 (A>T) (HBB:c.52A>T), codon 41 (− C), codons 41/42 (− TTCT) (HBB:c.126_129delCTTT), IVS1-1 (G>T) (HBB:c.92 + 1G>T), IVS1-5 (G>C), and IVS2-654 (C>T) (HBB:c.316-197C>T)], were identified as transfusion-dependent thalassemia cases who need regular blood transfusion to manage their clinical complications and survival. Here, GSTM1 is linked to thalassemia.